Larry F. Wolff MS, PhD, DDS



Office Address

17-164 Moos Tower
515 Delaware St. SE
Minneapolis, MN 55455
United States


Professor, Department of Developmental and Surgical Sciences


PhD, Northwestern University Medical and Dental School (Thesis: Studies on a bactericidal substance produced by Group A Streptococci), 1974
MS, Minnesota State University (Thesis: The radiation resistance of Micrococcus radiodurans), 1971
BA, Minnesota State University, 1970
Certificate, New York University Dental Center (Periodontics), 1980; DDS, University of Minnesota School of Dentistry (Dentistry), 1978

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Dr. Larry Wolff is a graduate of the University of Minnesota School of Dentistry. He received his PhD in Microbiology at Northwestern University, his DDS degree from the University of Minnesota and his certificate in Periodontics from New York University Dental Center. Dr. Wolff has been a full-time faculty member at the University of Minnesota School of Dentistry since 1980 and currently is a Professor in the Department of Developmental and Surgical Sciences. He has lectured extensively at the National and International levels in areas related to the use of antimicrobial agents as adjuncts to periodontal therapy and systemic conditions as related to periodontal disease. Dr. Wolff has numerous publications on topics surrounding the microbiology of periodontal disease and scientific investigations related to the clinical use of antimicrobials as adjuncts to periodontal treatment in dentistry and periodontics. Recently, Dr. Wolff has published extensively in the area of periodontal regeneration and tissue engineering.

Awards & Recognition

  • Distinguished University Teaching Professor Award (In recognition of excellence in instruction, advising, and mentoring of graduate and professional students) 2018/2019
  • Faculty of the Year Award (Outstanding Didactic Teaching in the School of Dentistry/University of Minnesota from the class of 2016) 2015
  • Didactic Faculty of the Year Award (Recognition of outstanding teaching in the School of Dentistry/University of Minnesota from the class of 2015) 2014


Research Summary/Interests

Dr. Wolff teaches and pursues research interests in the field of periodontology. His basic research interest focuses on the bacterial etiology of periodontal diseases, new diagnostic techniques to identify bacteria in plaque, the role of cytokines on the periodontal disease process, and the expression of virulence factors by periodontopathic bacteria and the host response to those virulence factors. On the clinical side, he's currently pursuing studies of antimicrobial therapy for the treatment of periodontal disease and is also exploring the relationship between periodontal disease and a variety of systemic conditions, including cardiovascular disease and diabetes. In the area of antimicrobial therapy, Dr. Wolff studies the role of local delivery of antimicrobial therapy and systemic antibiotics as adjuncts in treating periodontal disease. Other areas of current research interest include the effect of smoking on periodontal disease and as a risk factor for progressive periodontitis, subgingival temperature as a diagnostic aid, and the effect of sonic toothbrushes in reducing plaque and gingival inflammation around implants. More recently, Dr. Wolff has pursued interest surrounding tissue regeneration and growth factors as related to regeneration of the periodontium.


  • Chatzopoulos, G, Cisneros, A, Sanchez, M and Wolff LF. "Systemic Medical Conditions and Periodontal Status in Older Individuals". Special Care in Dentistry, 38(6):373-381, 2018. 1111/scd.12319
  • Bandt C, Pihlstrom B, Wolff LF, Bakdash B. Letter (Commentary) to the Editor. "Baking Soda Dentifrices". Journal of the American Dental Association. In Press, 2018.
  • Chatzopoulos, Georgios; Aiksaterini-Ellisszvet Doufexi; Larry Wolff and Anatasia Kouvatsi. "Interleukin-6 and interleukin-10 gene polymorphisms and the risk of further periodontal disease progression". Brazilian Oral Research, 32(11) 2018.
  • Chatzopoulos, Georgios S.; Vasiliki P. Koidou, Scott Lunos and Larry Wolff. ''Implant and root Canal Treatment: Survival rates and Factors Associated with Treatment Outcome”. Journal of Dentistry, 71:61-66, 2018.
  • Chatzopoulos, George and Larry F. Wolff. "Implant Failure and history of failed Endodontic Treatment: A retrospective Study". The Journal of Clinical Experimental Dentistry, 9(11):e1322-1328, 2017. https://doi:10.4317/jced.54277.
  • Chatzopoulos G, Cisneros A, Sanchez M, Lunos S, Wolff LF. "Validity of Self-Reported Periodontal Measures, Demographic Characteristics and Systemic Conditions". Journal of Periodontology, 89(8):924-932, 2018.
  • Chatzopoulos, Georgios S., Miguel Sanchez, Alejandro Cisneros & Larry F. Wolff. “Prevalence of temporomandibular Symptoms and Parafunctional Habits in a University Dental Clinic and Association with Gender, Age, and Missing Teeth". The Journal of Craniomandibular & Sleep Practice. Pages 1-9, 2017.
  • Chatzopoulos, G. & Wolff LF. "Implant and Endodontic Treatment Selection are influenced by Patients' Demographic Characteristics, insurance Status, and Medical History: A retrospective Cohort Study". Quintessence International 48(9): 753-764, 2017.
  • Chatzopoulos G, Wolff L. No association between para functional habits and Implant Failure. American Journal of Periodontology, Submitted, 2017.
  • Chatzopoulos G, Wolff L. Patients socio-economic status, tobacco use, and medical history associated with failure of dental implants. A retrospective case-control study. Journal of Oral Implantology. Submitted, 2017.
  • Chatzopoulos G, Koidou V, Wolff L. Systematic Review of Cyclosporine A-Induced Gingival Overgrowth and Genetic Predisposition, Quintessence International, 48(9):711-724. 2017
  • Kobayashi M, Kawase T, Okuda K, Wolff, L. Yoshie H. In vitro immunological and biological evaluations of the angiogenic potential of platelet-rich fibrin preparations: a standardized comparison with PRP preparations. International Journal of Implant Dentistry. 1:31, 2015. DOI:10.1186/s40719-015-0032-0
  • Okuda K, Najajima Y, Kawase T, Kobayashi M, Kamiya M, Horimizu M, Wolff LF, Yoshie H. Platelet-rich Fibrin Membrane Combined with Beta-Tricalciurn Phosphate for Treatment of Infrabony Defects in Chronic Periodontitis: A Case Series. Jacobs Journal of Dentistry and Research. 2(3): 022, 2015.
  • Kim JW, Wolff RE, Gaillard P, Wolff LF. Gingival crevicular blood as a source to screen diabetes control in a dental office setting. American Journal of Dentistry. 28(2):63-67, 2015.
  • Kawase T, Kamiya M, Kobayashi M, Okuda K, Wolff L, Yoshie H. The heat-compression technique for conversion of the platelet-rich fibrin membrane to a less biodegradable barrier membrane. Journal a/Biomedical Materials Research: Part B -Applied Biomaterials, 103:4; 825-831; 2015
  • Wolff L. Diabetes and periodontal disease. American Journal of Dentistry. 27(3): 127-128, 2014.
  • Horimuza M, Kawase T, Nakayama Y, Liuda K, Nagata M, Wolff L, Yoshie H. An improved freeze-dried PRP-coated biodegradable material suitable for connective tissue regenerative therapy. Crybiology. 33:281-287, 2013.
  • Okuda K, Kawase T, Nagata M, Yamamita K, Nakata K, Wolff L, Yoshie H. Five Year Results of Tissue Engineered Cultured Periosteal Sheet Application to Periodontal Regeneration: Case Series. The International Journal of Periodontics and Restorative Dentistry. 2013.
  • Gonzalez-Campoy M, Rhodus N, and Wolff L. Diabetes and Oral Health. Northwest Dentistry, 12-16. 2013. (This was the cover story for this volume of Northwest Dentistry.)
  • Gonzalez- Campoy M., Rhodus N, Wolff LF. Control your Diabetes for Life. Minnesota Dental Association News, November 2-3, 2012.